‘Yes, that is certainly about ideal. I hunt for a Actual physical understanding of biological units in the base-up way. I think you might distinguish a few lines of investigation in my team in the mean time. The 1st concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have developed visualisation strategies that allow for us to review how, as an example, SMC proteins loop DNA (movie on Youtube) in an effort to Establish up chromosomes.
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‘It was simply just a subject of choosing up a e-book on cell biology and beginning to go through. I had originate from a planet of ultra-significant vacuums, cryostats and quantum phenomena, and now I used to be Operating at home temperature with molecular biology kits.
Our do the job was rapidly adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 printed their results on transistors created from single- and multi-walled carbon nanotubes in Applied Physics Letters.
That could be a desire of mine and we set to operate with a delightful dose of naivety. This is often something that will most likely generate magnificent ends in the for a longer period phrase, but that doesn't make any difference. You should not only want to work to the questions of tomorrow, but additionally to the questions in the day immediately after tomorrow.’
Experimental phase diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is these factors collectively make up a dwelling program. The trick of mentioned everyday living, I believe, lies during the interactions, the interplay of All those molecules. The big concern regarding the origin of life remains to be unanswered. How did we at any time evolve from easy molecules in the very intricate systems we see nowadays? We do not know. I want to work on These types of significant, open inquiries.’
Nanopores characterize a sublime and functional Software to evaluate one molecules. We exploration novel detection modes with good-point out nanopores together with many methods to measure proteins with nanopores. Projects encompass the subsequent:
Comprehension elementary procedures regulating the spatial and dynamic organisation with the DNA in Stay cells.
But carbon nanotubes have remained a investigate subject matter of considerable interest to many. Indeed, the outlook on using carbon nanotubes to make simple equipment, in parts for instance radio-frequency electronics, digital electronics and flexible electronics, remains dazzling.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial cell division
‘That concerns the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter seemed top-down in People times and ceesdekker recognized about 5 hundred genes that are minimally necessary for just a working mobile. We want to search base-up: how can we move from a couple molecules to a complete biological process?
Visualization of unstained DNA nanostructures with Innovative in-concentration transmission electron microscopy techniques
It had been an exceedingly fascinating time, through which I received a great deal of aid from Delft College of Engineering, wherever I had been a professor at the time, and I commenced quite a few collaborations with molecular biologists. That helped me discover a good deal.’